[1] The CMS Female Institution was founded on 1 May 1869, ten years after the Church Missionary Society had founded CMS Grammar School, Lagos as the first boys grammar school in Nigeria.
Abigail Macaulay, wife of the boys' school headmaster, and daughter of Bishop Samuel Ajayi Crowther, had pressed for there to be a girls' institution, in order that rich people in Lagos no longer need send their girls abroad to study.
[2] The school, situated on what today is Broad Street in Lagos, initially had sixteen pupils.
Anna, and her husband's, tomb had been renovated by Kudeti Girls' School in 1933.
The school celebrates its 'birthday' on July 26, the feast day of Saint Anne.