Established in 1892 by the Capuchin Friars from Belgium, the school is part of the Roman Catholic Archdiocese of Lahore.

The school's main campus is situated at Lahore's historical road, The Mall, adjacent to the Sacred Heart Cathedral.

St. Anthony's was founded on 1 March 1892 in Peeli Kothi, Empress Road, Lahore by the Capuchin Friars from Belgium.

Capuchin Father Leo De Brabandere Petrus (1900 - 1902)[3] took over as the first principal of the school and started 'O' Level classes.

At the end of 1978 the Patricians handed the school over to the Irish Marist Fathers, the new principal Fr M. Donnelly (1979 - 1983).

[6] As of 2014[update] Archbishop Sebastian Francis Shaw was the chairman of the board of governors, H.D.Maxwell Shanthi the executive secretary, and Shahid Ambrose Moghul the principal.

The college was inaugurated by Cardinal Fernando Filoni in the presence of the Apostolic Nancio Edgar Pene Para and Sebastian Francis Shaw, the Archbishop of Lahore.

The ceremony was attended by friends and family members of the war hero, important personalities of the Christian community and significant civil and military dignitaries.

Co-curricular and extracurricular activities include debates, excursions, funday, bonfires, picnics, funfair, science model fair and annual sports.