The building was designed in 1910 by John P. Eisentraut's Black Hills Company, an architectural firm of Deadwood, South Dakota.

[5][6] In 1914 a priest house was built to the left of the cathedral, and a school was added in 1918 across the street.

[3] John Philip Eisentraut graduated with an architectural degree in 1894 at Northwestern University in Illinois.

The many stained glass windows are a key feature of catholic churches.

The main façade is brick, with cream colored voussoirs highlighting the curved windows.

[5] St. Anthony's Church was added to the National Register of Historic Places[5][3] on June 3, 1982 because of its architectural significance.