St. Anthony de Padua Parish School is a historic Catholic school building located in the Southwest Center City neighborhood of Philadelphia, Pennsylvania.

It was built in 1897, and is a four-story, red brick building with stone trim in the Romanesque Revival-style.

It has rounded arched window openings, a hipped roof with dormer, and freestanding brick fire tower.

[2] It was added to the National Register of Historic Places in 1992.

[1] It is currently used as senior housing.