Grades 9 to 12 are taught, with religious studies included in the curriculum.

It is named after Saint André Bessette (also known as Brother André), a 20th-century Catholic religious brother in Montreal responsible for the construction of the Saint Joseph's Oratory.

Brother André is located in east-central Markham, and its feeder schools include On April 28, 2010, a fire broke out at St.

Brother André Catholic High School in the boys' washroom on the second floor.

Former principal Jim Nicoletti said that there was a "minor" investigation in progress by the York Regional Police.