St. Andrew's was founded by Bishop Burchard of Würzburg (742-53) on the left bank of the Main at the foot of the Marienberg shortly after 748.

In 986, Hugo von Rothenburg, Bishop of Würzburg, refounded the abbey and once again called Benedictines to the place.

In late Medieval times life in the abbey significantly deviated from the Benedictine rule.

[1] Yielding to the request of the monks, Pope Pius II, in a papal bull dated 4 February 1464, changed the abbey church into a collegiate church (Ritterstift), and permitted the former monks to remain as canons.

[1][2] Due to the possession of significant forest properties the abbey had sufficient income throughout its history.

As a consequence, Bishop Julius Echter von Mespelbrunn temporarily put St. Buchard under forced administration.

[1] During the Thirty Years' War the abbey wasa sacked by Swedish troops and the church was severely damaged.

[1] In 1663-7, Bishop Johann Philipp von Schönborn had the original west choir, western transept and western tower demolished to make room for a new fortification of the slopes beneath Marienberg Fortress and a shipping canal.

[1] On 16 March 1945, during the Allied Bombing of Würzburg in World War II the church was mostly spared.

The Romanesque three-aisled nave, the two towers and the north portal from the times of the Salian dynasty are partially still extant.