A high quality example of Italian Renaissance Revival architecture, it is emblematic of the shift on Waltham's south side from a predominantly Protestant population to one of greater diversity.

It is a tall cruciform structure with no tower, built out of terra cotta brick with stone trim.

[2] The Roman Catholic Archdiocese of Boston decided in 1909 to establish a second parish in Waltham, and services were first held in a community hall on Moody Street later that year.

[2] In 2014, the parish began to be jointly administered with St. Mary's, though regular Mass continued to be celebrated at St. Charles', usually in its smaller chapel.

[3] The property was sold to Waltham-based developers Hall Street Partners, who are converting the structure to condominiums set to be occupied by the end of 2024.