In 2011, Saint Charles East had an average composite ACT score of 19.0 and a graduation rate of 89.8%.

[4] In 2012, the Saint Charles East team finished first at the state Science Olympiad Single A Division held at the University of Illinois.

[citation needed] The Theater Department produces three shows per year, including one musical.

[8] In 1978/79, the fledgling St. Charles High School Boys' Swim Team won its first state championship.

[11] Swimming World Magazine named St. Charles the public high school girls' "Team of the Year" in both 1999 and 2000.

Prior to moving to its current location in 1977, the high school was located in the middle of town at the corner of Main Street and Seventh Street, in the building that now serves as Thompson Middle School.

During spring break in 2001, a serious black mold problem was discovered at the campus (Stachybotrys and Aspergillus).

In 2001, the building was shut down and the students remained on an extended spring break while officials struggled with the issue.

For the entire 2001–2002 school year, the current students had to take classes in the adjacent Wredling Middle School building and mobile classrooms surrounding it (brought in specifically to accommodate the larger student body).