It is served by the daily Empire Builder on its route connecting Chicago, Illinois to Seattle, Washington and Portland, Oregon.

There is an enclosed waiting room (with restrooms) available daily from 4:00 am to 6:00 am and from 11:30 pm to 1:15 am (early the next morning), with a caretaker opening and closing the depot.

Cloud station was served by the North Coast Hiawatha, with service from Chicago to Seattle from 1971 until the train was discontinued in 1979.

[4][10] The station is one of three in Minnesota and 78 across the Amtrak network listed in a 2021 settlement with the U.S. Department of Justice over inaccessible facilities under the Americans with Disabilities Act.

[11] New station platforms, walkways, lighting, and other accessibility improvements will be constructed between Amtrak's fiscal year 2024 and 2026.

[14] The station was considered as a possible endpoint for the Borealis service that started running in 2024, but it began operation with its western terminus in St.