It is in the peninsular part of the city at the Largo de São Domingos, near the Leal Senado Building.

[4] It was the scene of violence in 1644, when a Spanish officer—loyal to the King of Spain and opposing the colony's determination to stay allegiant with Portugal after the dissolution of the Iberian Union—entered the church in order to seek refuge from an angry mob.

[6] The church closed down in 1834 when monastic orders were dissolved and expropriated to the government, who then converted it into barracks, a stable and an office for public works.

[5] The church of St. Dominic was built in a Baroque style[8] and is noted for its mixture of European and local Macanese features in its design.

[5][10] The Treasure of Sacred Art Museum[9] was established as part of the 1997 renovation and is located inside the church's bell tower.