Catholic priests began serving the area around DeValls Bluff in the 1870s, and St. Elizabeth's was canonically established as a parish of the Diocese of Little Rock in 1904.

As large Catholic immigrant communities settled in the area in the early 20th century, mostly German and Austrian farmers, the parish outgrew its first church and had the present structure built in 1912.

[2] In 1992, local resident Mary Sharp purchased the property from the diocese, having a personal interest in the church and in the history of the region, though not a parishioner or Catholic herself.

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