St. Francis, also known as Sápauŋ thí [5](Lakota: Sápauŋ thí; "Catholic House") is a town in the Rosebud Indian Reservation in Todd County, South Dakota, United States.

[7] According to the United States Census Bureau, the town has a total area of 0.36 square miles (0.93 km2), all land.

There were 211 housing units at an average density of 586.1 per square mile (226.3/km2).

19.0% of all households were made up of individuals, and 2.6% had someone living alone who was 65 years of age or older.

There were 204 housing units at an average density of 562.4 per square mile (217.1/km2).

21.3% of all households were made up of individuals, and 9.3% had someone living alone who was 65 years of age or older.

Saint Francis has a representative from its district on the Rosebud Tribal Council.