St. Francis DeSales High School is located on the north side of Columbus, Ohio.

Students come from the Columbus Public School District and suburban school districts: Big Walnut, Delaware, Gahanna Jefferson, Lewis Center, New Albany-Plain Local, Olentangy, Westerville and Worthington.

It had ten sisters from St. Francis of Stella in Niagara, New York, four priests, and eight lay people.

[2] St. Francis DeSales High School is the recipient of two Blue Ribbon Awards of Excellence in Education.

Since 2021, catechesis at the school has been facilitated by Salesian Sisters of Don Bosco.