In fall 2018, St. Francis opened a high school on the Couper Campus (2300 S. Piney Point Rd., Houston, TX 77063), and its inaugural freshman class graduated in 2022.

Between 1978 and 1985, capital campaigns funded the construction of a gymnasium, dining hall, additional classrooms, and the Sarah W. Woolrich Education Building.

Today, the school serves students from age 2 years through 12th grade on two sites - the original Piney Point Campus and Couper Campus - together totaling 39 acres providing ample room for the school's 600-seat state-of-the-art Fine Arts Center, 7,000-square-foot library and technology center, and nine acres of regulation playing fields for a wide variety of sports.

[6][7] Since its founding, St. Francis has been led by six heads of school: Sarah Woolrich (1965–1986); Dr. Kay P. Walther (1986–1993); Dr. Annette Smith (1994–2000); Dr. Susan Lair (2001–2017); Stephen Lovejoy (2017–2022); and Dr. Chelsea Pope Collins (2023–present).

On July 30, 2020 at approximately 10:30pm, a fire broke out in the historic house at the south campus.

The school raised funds for a brand-new building on the site, which was completed in early 2023.