In 1849, the directors of the association were discovered to have been selling plots to non-Catholics, which was a violation of church law.

This was possibly due to the large number of burials resulting from a cholera outbreak in the city that year.

Due to the scope of the project and the terrain, construction was completed only in late 1888 and the hospital dedicated by the Archbishop of Cincinnati, William Henry Elder, in December.

The hospital opened under the direction of Sister Apollonaire, S.P.S.F., on January 2, 1889, and numbered nearly 800 patients by the end of the year.

[2] The successor hospital subsequently joined Cincinnati's Mercy Health care system, becoming its Western Hills Medical Center[4] which closed c. 2013 as community needs shifted.