St. Francisville or Saint Francisville is an unincorporated community and census-designated place in northeast Clark County, Missouri, United States.

[4] The community is on Missouri Route B four miles north of Wayland.

The Des Moines River and the Missouri-Iowa border are one-half mile north of the community.

St. Francisville was platted in 1833, by a man named Francis Church.

This Clark County, Missouri state location article is a stub.