According to John Stow, writing during the reign of Elizabeth I, the church had escaped the depredations of Tudor looting since its monuments "were well preserved from spoil".

Adam Bamme, the mayor of London who died in office on 6 June 1397 (and from whom Richard Whittington took over), was buried in St George Botolph Lane.

An unusual feature of the church was that it was built on a stylobate; the site was originally low-lying and sloped downhill towards the Thames, so Wren raised the level and made it even by the construction of a platform.

Its east front, facing Botolph Lane, consisted of three bays, the central one of which projected, and was slightly wider.

William Beckford, twice Lord Mayor of London: whose incessant spirited efforts to serve his country hastened his dissolution."

The church's proximity to Billingsgate fish market prompted James Peller Malcolm to write "The narrow streets and alleys and their wet slippery footways will not bear description or invite unnecessary visits".

The last service was held in 1890, and in May 1900 a letter to The Times reported that not only had the church been condemned as structurally unsafe, but that the accumulation of human remains in the vault had become a health hazard.

The churchyard gates survive in Lovat Lane, and a parish boundary mark can still be found on Fish Street Hill.