On Sunday, May 25, 1919, Metropolitan Germanos Shehadeh of Zahle, assisted by Archmandrite Seraphim Nassar, dedicated the church edifice.

The parish has grown throughout the years as more Orthodox faithful have migrated and immigrated to the area.

The city of Lowell is unique in that approximately one-fifth of the population is of the Eastern Orthodox faith.

The most prominent of these are the breathtaking image of the Holy Virgin (Platytera) in the church apse and the majestic icon of the Pantocrator (Jesus) directly overhead.

It was included on the National Register because of the church's association with immigrants who worked in the mills that made Lowell the center of the American Industrial Revolution.