St. Gregory the Great High School was a private, Roman Catholic high school in Chicago, Illinois, specifically in the area of West Edgewater.

It was part of the Roman Catholic Archdiocese of Chicago.

[2] In 2012, the Chicago Archdiocese and the school administration announced that, after 75 years, it would close.

All remaining students were transferred to Holy Trinity High School at the end of the 2013-14 academic year.

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