St. Jerome in His Study is an oil on panel painting by the German Renaissance artist Albrecht Dürer, completed March 1521.

The artist donated the painting to the head of the Portuguese trade mission in the Netherlands, Rodrigo Fernandes de Almada.

Among Dürer's depiction of St. Jerome, this is the one more resembling a portrait, with little space left for the study and its details (such as in his 1514 etching, where the saint is a small figure in the background).

The subject is portrayed with great attention to detail,[1] including the wrinkles to the white-yellowish beard.

Also differently from the etching, the memento mori suggestion of the finger above a skull has a greater visual relevance.