St. John's Lutheran Church and Cemetery is a historic Evangelical Lutheran church and cemetery and national historic district near Wytheville, Virginia, United States.

The church was built in 1854 and is a rectangular, three bay by two bay, frame church sheathed in weatherboard.

It measures 45 feet by 55 feet, has a gable roof, and sits on a limestone basement.

The adjacent cemetery includes a notable group of approximately 30 early-19th century, German-style monuments.

[3] It was listed on the National Register of Historic Places in 1978.