It is located in the neighborhood of Four Mile Run, which is an isolated section of Greenfield at the bottom of Junction Hollow.

Because it faces the heavily traveled Interstate 376, or Parkway East, it is an architectural landmark for many commuters who look upon its onion domes and Slavic-style crosses.

Large numbers of Rusyns settled in a small valley called Four Mile Run, a part of the Greenfield neighborhood and adjacent to a large steel mill of the Jones and Laughlin Steel Company.

Alexij Petrasovich assumed his duties in August 1910, and the same year the church purchased five lots on Saline Street.

Andy Warhol was baptized here and the Warhola family worshiped at the church during the artist's formative years (1928–1949) in Pittsburgh.