SJPII, the first Catholic high school to be founded in Tallahassee, opened in 2001.

SJPII has an active drama department, a chorus that competes statewide in choral competitions, and a creative arts department that has competed in art competitions and exhibited at various Tallahassee museums and shows.

St. John Paul II puts on an annual arts and music festival known as SouthWoodStock featuring student and outside artists and musicians.

St. John Paul II High School's mascot is Pep the Panther, and their colors are Blue and Gold.

John Paul II School hosts the District volleyball, basketball and baseball events.