It runs for around 1.34 miles (2.16 km) from Brighton Avenue (part of Maine State Route 25), in the north, to Valley Street, in the south.

It crosses Park Avenue (part of Maine State Route 22) and Congress Street and passes beneath Interstate 295.

Beside that location, to the south, is the Maine Central Railroad General Office Building, which was completed in 1916.

[4] A spur of the Portland and Ogdensburg Railway from Union Station crosses Maine Central Railroad's trestle bridge at St. John Street and Park Avenue.

The line continues behind Hadlock Field and Fitzpatrick Stadium before ending at Forest Avenue, beside Deering Oaks Park.