It is located at 210 Greentree Road in Munhall, Pennsylvania, a suburb of Pittsburgh in the Monongahela River valley.

In need of a larger church, in the summer of 1902 two lots were acquired on the corner of Tenth and Dicksons Streets in the newly created (from Homestead) borough of Munhall.

It was designed by the Hungarian-born architect, Titus de Bobula, and patterned after the Rusyn Greek Catholic Cathedral of the Exaltation of the Holy Cross in Ungvár, Austria-Hungary (today Uzhhorod, Ukraine).

The church's twin towers, which rise 125 feet (38 m), are composed of white brick in a Greek cruciform pattern set into sandstone.

In 1978, the parish acquired 18 acres (73,000 m2) of property off Greentree Road in Munhall and built the current Cathedral, which was completed in 1993.