[3] It is located at San José Street 25 in the city of Gualeguaychú, Entre Ríos,[4] The first stone was placed on May 30, 1863 under the patronage and in the presence of then-governor-general Justo José de Urquiza.

It was dedicated and consecrated in 1890 by the parish priest Luis N. Palma.

The parish church was elevated to cathedral status on June 29, 1957, through the bull "adoranda Cuandoquidem" of then Pope Pius XII, with the rise of the diocese.

The Eclectic style, which was the mainstream at the time of its construction, is visible in its fine architectural lines and neoclassical facade, which includes a portal with columns crowned by a low triangular pediment and flanked by two towers.

It preserves among other treasures, an image of the Our Lady of the Rosary of more than 170 years of antiquity.