Built 1864–67, it was the first Roman Catholic church in the city, and is one of only two surviving buildings in the state designed by Patrick C. Keely.

[2] Roman Catholic services began in Lewiston in the late 1840s, provided by traveling priests.

[2] The church served the diocese until it was closed in 2009; its stained glass windows and frescoes were then removed from the building.

It was purchased in 2013 by Central Maine Healthcare (CMHC), which announced plans to raze the church and the adjacent rectory.

Demolition of the church was delayed to allow alternative uses for the building to be identified,[3] but the rectory was demolished in April 2015.