It is part of the St. Joseph's Health System and serves as the regional kidney transplant centre for a population of approximately 1.2 million people.

With three locations in Hamilton, the hospital is known for being one of the top national institutions for robotic surgery and for having one of the largest kidney and urinary programs.

[citation needed] It's also first in Canada to partner a mental health worker with police to respond to a 911 crisis call.

[3] St. Joseph's Healthcare Hamilton's West 5th Campus provides specialized tertiary mental health services for residents of Central South Region in Ontario, operating specialized mental health beds and providing leading-edge community services to thousands of outpatients.

The Regional Eye Institute (providing eye care and cataract surgery) is located here; the site is primarily for outpatient services, including pain management, a Mature Women's Health Centre, a 39-bed satellite Dialysis Clinic, and education programs.