It is located in the district of Pandacan in the City of Manila, Philippines, established by Cardinal Rufino Jiao Santos, D.D.

in 1955 to provide a school that would enable the children of Pandacan and its neighboring towns an opportunity to receive good Roman Catholic oriented education.

The collaboration of Cardinal Rufino Jiao Santos, the Sisters of the Immaculate Heart of Mary (ICM), who were also planning to build a school in Pandacan, and Sto.

Niño Parish Priest Guilermo Mendoza led to the establishment of St. Joseph's School's very first building at the adjacent vacant lot to the Sto.

The school's enrollment continued to grow, however, with some classes being held in makeshift classrooms in the Parish Office building.

This annex to the high school building was blessed and opened on November 28, 1971, by Cardinal Santos with Bishop Bienvenido Lopez and Parish Priest Victor Serrano.

The three symbols in the logo aptly convey Saint Joseph's main character: pure, holy, and just; hardworking; and protector and defender against evil and harm.