Martin Spalding, Bishop of Louisville, himself came to Four Mile Creek in August 1853 and was instrumental in the founding of the parish.

It is notable for the rich iconography of its interior decor, including altarpieces and murals, mostly installed under the pastorship of Fr.

In the 1920s, the church's murals were painted by Leon Lippert, a student of noted Covington artist Frank Duveneck.

[6] The statue of Our Lady of Sorrows was donated in 1926 by Emma Ritter, and marble work in the sanctuary was completed by Bert Moriconi and painted in the 1940s.

This article about a property in Campbell County, Kentucky on the National Register of Historic Places is a stub.