Located in the upper part of the city, the cathedral was built on the hill of Ambohimanoro, near the Andohalo square, and has now been designated as a national heritage by the Malagasy government.

[2][3] During this time period Anglican missionaries from the Society for the Propagation of the Gospel were sent to Madagascar.

He resided near Ambohimanoro where his congregation met in a small wooden church at Ambatomasina, near the cathedral's current location.

[4] The church was designed by English architect William White and built by Norwegian Alfred Anker in the neo-Gothic style.

[4] In October 2017 Princess Anne attended a Service of Thanksgiving to commemorate the 200th anniversary of the Diplomatic relationship between Madagascar and the United Kingdom at the cathedral, alongside Madagascar president Hery Rajaonarimampianina during her visit to the country, making it the highest-ranked member of the British royal family to officially visit the location.