St. Leo's Church is a historic Roman Catholic church complex located within the Archdiocese of Baltimore in Little Italy, Baltimore, Maryland, United States.

The church was built in 1880-81 of brick with stone trim, and combines Italianate, Romanesque, and Classical elements.

It features a high entrance porch, a turret with conical roof on the north wall, a square bell tower at the northeast corner, a large rose window in the main façade, and a variety of decorative brickwork.

It was the first church in Maryland, and among the first in the nation, founded and built specifically for Italian immigrants.

[2] St. Leo's Church was listed on the National Register of Historic Places in 1983.