The Beach Boys had based their number 3 hit single "Surfin' U.S.A." on his "Sweet Little Sixteen"; the Beatles had included "Roll Over Beethoven" on their second American album;[5] the debut single in the United Kingdom by the Rolling Stones was their cover of "Come On", and they had included "Carol" on their first American album, England's Newest Hitmakers.

[6] Wishing to capitalize on his popularity during the British Invasion, Berry and Chess Records fashioned this album to appeal to young buyers.

St. Louis to Liverpool includes four of the five charting singles he enjoyed in 1964, the final year he would have multiple records appearing on the Billboard Hot 100: "No Particular Place to Go", "You Never Can Tell", "Promised Land", and "Little Marie", a sequel to "Memphis, Tennessee".

On April 13, 2004, the Chronicles division of the Universal Music Group remastered the album for CD with three bonus tracks as part of its 50th anniversary commemorative of Chess Records, including "O'Rangutang", the flip side of the fifth of his 1964 charting singles "Nadine (Is It You?

In 2008, Mobile Fidelity Sound Lab reissued the album with Berry Is on Top on an Ultradisc II Gold compact disc.