The church complex of four buildings and a cemetery takes up a 12-acre (4.9 ha) parcel between Wolcott (NY 9D), Rector, Phillips and Union Streets.

[1] St. Luke's is a one-and-half-story asymmetrical cruciform building faced in Schenectady bluestone in an ashlar pattern with Ohio sandstone trim.

The floors in the center and side aisles are laid in a polychrome glass pattern, with carpet covering the area under the pews.

It is a likewise asymmetrical two-and-a-half-story structure of bluestone walls with brick trim, rebuilt to its original plan after a fire.

A fireplace within it retains a cast-iron decorative plate from the rectory at the church's earlier location in downtown Beacon.

Two notable examples are a brownstone marker with a crocketed pinnacle whose date and decedent cannot be determined, and the Neoclassical monument of Isaac Van Nostrand, with a base, plinth and fluted Roman Doric column.

Withers, already having been exposed to this in his native England, had professed his allegiance to Ecclesiological principles in an 1858 essay, "A Few Hints on Church Building".

His brief work with Andrew Jackson Downing and fellow English immigrant Calvert Vaux prior to the former's death had further strengthened his appreciation for the Picturesque mode of the Gothic Revival[1] Withers' design strongly reflects Downing's ideals of church design, of a building that harmonizes with the surrounding natural landscape.

Several features, such as the broad nave, full transept, deep chancel, large south porch and frame bell cote, are exactly as prescribed by Ecclesiological writers.

In his 1873 book Church Architecture, he devoted a great deal of text and an illustration to St. Luke's, suggesting he was very proud of how it turned out.

[1] The Rectory likewise reflects Withers' less conservative visions of domestic architecture on a smaller scale than his usual work, with its irregular and asymmetrical roofline and alternation of brick and stone.

Its most notable Picturesque feature is the irregular placement of its trees apart from those that border the path from the church and the streets surrounding the plot.

So, in 1832, three local sisters began offering religious instruction to children at their house, today's Madam Brett Homestead.

Their parents and other adults met in a dry goods store, and by the end of the year the group had reached the size where it could form a parish of its own.

In 1833 it formally incorporated as St. Anna's, and the next year built a small brick church with columned portico at what is now the intersection of Main Street and Tioronda Avenue on donated land.

[1] The deed stipulated that a religious edifice of at least $20,000 in value ($416,182 inflation adjusted 1866 value) had to be built on the property within three years of its conveyance to the church.

During that period, the church building itself also got a new heating system, carpet for the floor under the pews, and the current roof tiles.

The parish continues its worship and ministries, including the food pantry program, and maintains both former church campuses.