St. Luke's General Hospital (Irish: Ospidéal Ginearálta Naomh Lúcás) is a public hospital located in Kilkenny, County Kilkenny, Ireland.

It is managed by Ireland East Hospital Group.

[2] New facilities, including a new accident & emergency department, acute medical assessment unit, day services unit and education centre were completed in 2016.

[3][4] The hospital provides 285 beds, of which 228 are in-patient acute beds, while 12 are reserved for day cases.

A further 45 beds are designated for in-patient psychiatric care.