It provides general medical and surgical facilities, ambulatory care, and a Level II Trauma Center, verified by the American College of Surgeons.

Mount Sinai Morningside is the primary provider of health care serving the neighborhoods of the Upper West Side and western Harlem.

It operates 21 clinics and as of 2020, is nationally ranked #23 for Diabetes and Endocrinology, and #25 for Nephrology by U.S. News & World Report.

Parts of the facility have been designated as an official New York City landmark, and the remaining pavilions of the original hospital are listed on the National Register of Historic Places.

[9] St. Luke's was founded by William Augustus Muhlenberg, pastor of the Episcopal Church of the Holy Communion.

[12] The hospital received its first patients in 1853, initially operating within the Church of the Holy Communion building at Sixth Avenue and 20th Street in present-day Chelsea.

[12] John W. Ritch designed a new brick building in the Romanesque Revival style, which was composed of two wings flanking a central pavilion.

[14][15][17] A training school for nurses was founded in 1888, and three years later, tuberculosis patients were moved to a facility in Tremont, Bronx.

George Macculloch Miller, who had led the purchase of the Cathedral of St. John the Divine's land in Morningside Heights, had been interested in a partnership with St. Luke's Hospital for five years.

[14] By 1892, Miller had convinced the hospital to purchase the site directly north of the cathedral, between 113th and 114th Street.

[15][20] Renwick and Clinton declined to enter the competition, and other architects submitted plans without receiving compensation.

[20] The competition was mildly controversial: the Real Estate Record and Guide said that because competitors could not use pseudonyms, the judges could more easily identify the architects that they favored.

[23] Flagg likely benefited from favoritism:[10][23][24] he had been described as a "surrogate son" of Cornelius Vanderbilt II, who was part of St. Luke's executive and building committees,[25] and had no previous design experience.

[29][30] The project was beset by delays and disputes due to Flagg's combativeness toward suppliers: he objected to the quality of such materials as the marble, steel, and stained glass.

Despite this, the trustees chose to remain within part of its Fifth Avenue campus and turn the rest over to the new owners,[32] the Union Club of the City of New York.

Affluent patients at first avoided St. Luke's due to the lack of a private pavilion, hurting its business.

[32][37] By 1901, St. Luke's board was preparing plans for a private patients' pavilion, though such a structure could not be built until funds were provided.

[37][38] Though Flagg submitted designs for the Plant Pavilion,[37] there is insufficient evidence to determine whether he supervised the construction process.

[39] After Flagg submitted plans in early 1904, work started on the Plant Pavilion in April 1904,[40][41] and after a delay caused by a labor strike,[41] it was completed in 1906.

[47] On January 9, 1997, St. Luke's–Roosevelt entered into a partnership with Beth Israel Medical Center and New York Eye and Ear Infirmary, forming the Greater Metropolitan Health Systems, Inc.

In April 1998, Greater Metropolitan Health Systems, Inc., was renamed Continuum Health Partners, Inc.[48] The Plant and Scrymser Pavilions for Private Patients were designated by the New York City Landmarks Preservation Commission as official city landmarks in 2002.

[57] The plan was a continuation of previous hospital designs that had split the wings into several pavilions connected by arcades.

[44] In the final design, the board decided to move the administration building closer to the street and to remove the proposed gatehouses.

[52] The Plant and Scrymser Pavilions are located on Morningside Drive, on the eastern part of the hospital site.

[39][44] Scrymser, one of Flagg's final commissions in Manhattan, was nine stories tall and differed from the other pavilions, in that it contained upper terraces with loggias (rather than a mansard roof), as well as a brick facade with muted ornamentation.

[63] Named for the hospital's founding president Robert Minturn, it initially served as a women's surgical ward.

[70] From South Carolina, Sims had developed a revolutionary approach to treating vesico-vaginal fistulas, a catastrophic complication from obstructed childbirth.

Thomas Addis Emmet, who served at the hospital, published the first comprehensive textbook in English on gynecology.

[71] In 1867 Woman's Hospital moved to a new location on Park Avenue, at the present site of the Waldorf Astoria New York.

It was founded by Annie Ayres, a devotee of St. Luke's founder Muhlenberg and graduated 4,000 nurses during its 80-year run.