Saint Luke's Lutheran Church, once known as The German Evangelical Lutheran Saint Luke's Church, is a historic Lutheran church located on Restaurant Row at 308 West 46th Street between Eighth and Ninth Avenues in the Theater District of Manhattan, New York City.

St. Luke's was founded as a Dutch Reformed congregation in 1850, first meeting in rented rooms on the third floor of a building on 35th Street and 9th Avenue.

[2] Finally, the congregation acquired property at West 46th Street to build its current church.

An independent congregation without synodic affiliation since 1880, St. Luke's joined the Evangelical Lutheran Church in America in 1987.

[2] The architecture has been described as a happy marriage between the Gothic Revival and Art Deco styles.