[3] The hospital was designed by architecture firm RR Payumo and Associates and the construction costed around ₱9 billion.

[4] A joint venture between First Balfour and Makati Development Corporation was involved in the construction of the hospital.

[5][6] Upon its inauguration the health facility hosts a 14-storey nursing tower with a capacity of 600 beds, a helipad and a podium, along with an 11-storey medical arts building which can house clinics for 374 doctors and a ground floor with lobbies described as "hotel-like", and a multi-level parking with at least 1,000 parking slots.

[3] In January, 2024, St. Luke’s Medical Center unveiled the first in the Philippines latest version of da Vinci Surgical System in its main lobby.

[8] United States based magazine, Healthcare Management News and Insights, list St. Lukes Medical Center - Global City as part of its "World’s Most Beautiful Hospitals" on its March 2012 issue where the hospital was ranked 11th out of the 25 listed.