Completed in 1869, it is a prominent example of Gothic Revival architecture designed by that style's leading proponent, Richard Upjohn.

It is one of Upjohn's last designs, and was funded by the congregation, which contained eight millionaires whose fortunes were made in the coal fields and railroad industry.

It is set partly on natural terrace in a steeply sloping hillside, which has been extended and supported by a stone retaining wall.

The interior is lavishly appointed, with English Minton tile, Black Walnut, and stained glass windows by Louis Comfort Tiffany and Charles Gibson.

Packer's daughter Mary Packer Cummings funded a major renovation project that connected the church and the Memorial Building with an Otis Cage Elevator and installed a new Austin Company pipe organ.