The St. Mary's Academy Historic District is a religious building complex located at 610 W. Elm Avenue in Monroe, Michigan.

In 1846, the opened St. Mary Academy as a boarding school for girls, then located at the corner of Monroe and Elm.

By 1904, a second building was needed; this was constructed at the current site of St. Mary Catholic Central High School.

[2] In 1945, an all-boys school, Monroe Catholic Central, was established at the previous site of the St. Mary Academy.

The building is Gothic in style, made of soft-tone variegated brick with stone trim.