St. Mary's Church is an historic, former American Catholic church that is located in the Lawrenceville neighborhood of Pittsburgh, Pennsylvania.

Built in 1874, this historic church building was added to the List of Pittsburgh History and Landmarks Foundation Historic Landmarks in 1971.

St. Mary's Church remained in use by the new parish for a few years but closed in 2004 when operations were consolidated at St. Augustine.

In 2007, the former St. Mary's buildings were purchased by the Catholic Cemeteries Association, which administers the adjacent St. Mary Cemetery.

The church building was converted into a chapel for the cemetery.