St. Mary's Roman Catholic Church and Rectory are located in downtown Rochester, New York.

[1] The cornerstone of the church was blessed 18 September 1853 by Bishop of Buffalo John Timon (the Diocese of Rochester was not formed until 1868).

[1] It was where celebrated actress and ballerina Giuseppina Morlacchi and cowboy scout and actor Texas Jack Omohundro were married on August 31, 1873.

[1] A spire and belfry, designed by Richard B. Arnold, were added in 1939-1940,[1] and a 10-note Deagan tower chime was installed in time to be played for Christmas 1939.

The north tower may have been intended to have a spire originally, but financial difficulties may have precluded adding it earlier.