St. Mary's Episcopal Church was built in 1857 to serve approximately 20 plantation families in the remote Tunica area north of St. Francisville, Louisiana.

The church's design is attributed to Frank Wills, a New York architect who was a prominent proponent of the Gothic Revival style in the 19th century.

Wills believed that the English country church was the ideal model for American Episcopal congregations, a belief reflected in St. Mary's design.

The church was built on the Old East Tunica Road on 5 acres of land donated by Sarah Mulford.

[1] Its nomination describes it as " an elegant and generally well proportioned example of mid-19th century Gothic Revival ecclesiastical architecture.