[1] Founded by the Jesuits in 1864, the school is affiliated with the Indian Certificate of Secondary Education (ICSE).

Later it opened to the Catholic populace in general, which led to expansion and to the construction of the building that now houses the senior school, whose foundation stone was laid by Lord Linlithgow, the Viceroy of India from 1936 to 1943.

The school offers various sports facilities to the students, which include a gymnasium, basketball arena, and two grass turfed football grounds.

[5] St. Mary's switched to the ICSE Indian Certificate of Secondary Education curriculum in the year 1958 – thereby, becoming one of the early adopters of the system.

In recognition of its contribution in the field of education the Chief Postmaster General for Maharashtra released a special postal cover commemorating the school's 150th anniversary on 7 December 2013.