St. Mary Catholic Central High School, known colloquially as SMCC, is a Catholic, co-educational, parochial, secondary school located at 108 West Elm Avenue in Monroe, Michigan.

The school itself is listed as a contributing property within the St. Mary's Church Complex Historic District.

The name St. Mary Catholic Central comes from the two schools that formed it: St. Mary Academy (SMA) and Monroe Catholic Central High School (MCC).

In the inaugural school year of SMCC (1986–1987), the St. Mary Academy building was named “St.

In the 1987–1988 school year, the building of St. Mary Academy was no longer used, with all classes held at the east campus of SMCC which was Monroe Catholic Central.

SMCC became one of the first schools in the nation to fully implement the use of digital textbooks in place of traditional hardcover or softcover texts.

SMCC teams are part of the Michigan High School Athletic Association, and the Huron League.