The congregation met in the first Vanderburgh County Courthouse until January 12, 1840, when the first church building on 1st and Chestnut was consecrated by Bishop Jackson Kemper.

During the Great Depression when nearby Episcopal churches could not afford full-time clergy, he made time to visit these parishes for services to keep them open.

He formed a cadre of laypeople assist him in these services, which became known as the Evansville Associate Mission of Southwestern Indiana.

He held the position of National Field Secretary for the Church League for Industrial Democracy, which brought him into contact with activists AJ Muste & Claude C Williams, Leon Trotsky's bodyguard Henry Schnautz, and other socialists of the 1930s.

Moore & the vestry invited a group of black workers in the Civilian Conservation Corps & their African-American Episcopalian chaplain to worship at St. Paul's on Sundays - the first documented integrated church service in Evansville.

Moore brought future Supreme Court justice Thurgood Marshall to Evansville for help in creating a local chapter of the NAACP.

The flood damage later contributed to the shorting out of wiring connected to the organ, causing a massive fire on March 27, 1938.

Imri Blackburn became rector and served until February 14, 1954 when he resigned to accept a professorship at Seabury Western Seminary.