St. Rose of Lima Mission is a Roman Catholic church in Silver Lake, Missouri, in the deanery of Ste.

The parish first started as a log cabin mission church which was served by the Vincentians from Perryville in the 1850s.

Father Moore, who studied at St. Mary's of the Barrens Seminary, would later serve as priest at St. Rose of Lima Mission church.

In the early 1870s, Father Joseph Hellwing, who had just become pastor of St. Mary's at Biehle, also gave services here.

The brothers and students at St. Mary's of the barrens donated 30,000 shingles for the roof of the new church.