Sabinus of Spoleto (died c. 303) was a bishop in the early Christian church who resisted the Diocletianic Persecution and was martyred.

Diocletian's order required all Christians to sacrifice to the Roman gods or be put to death; their estates were then to be seized for the state.

Venustian mocked Sabinus's faith, accusing him of leading the people to the worship of a dead man.

The deacons were in great fear, but Sabinus encouraged them to hold to their faith, and they died after being torn apart by iron hooks.

Lucius had Venustian, his wife, and his two sons beheaded at Assisi, and he had Sabinus beaten to death at Spoleto.