It is situated on the corner of Hoskin Avenue and St. George Street in Toronto, next to Massey College.

Before the site was a church, it was a coach house attached to the home of Wilmot Deloui Matthews.

[1] From 1913 to 1936, the Newman Centre and chapel were served by the Paulist Fathers at St. Peter's Church, Toronto.

[1] The roof is supported by arch-braced trusses and beams made of dark stained British Columbia fir.

It originally featured two windows near the entrance depicting the patrons of the church, Thomas Aquinas and John Henry Newman.

[2] The windows installed in the west wall of the church in 2000 show Pope John XXIII, Kateri Tekakwitha, Jerzy Popiełuszko, Georges Vanier, Pauline Vanier, Gianna Beretta Molla, Franz Jägerstätter, Mother Teresa, Edith Stein, Thérèse of Lisieux, Óscar Romero, Pier Giorgio Frassati and André Bessette.

Their music ministry consists of a full rhythm section, violin, multiple cantors, and choir.