The 2,600,000 sq ft (240,000 m2) facility, situated on a 635 acres (2.57 km2) site,[1] opened in 1967, building the Ford Falcon.

[2] Ford's plans for sustainability and reduction of fossil fuel consumption relied on the St. Thomas Plant and its Lincoln Town Car vehicles for years.

Following the closure of the Wixom Assembly Plant in Michigan, production of the Lincoln Town Car (which was the only Ford Panther platform vehicle to be produced at the Plant) moved to St. Thomas Assembly starting with the 2007 model year.

[4] The plant had been largely demolished by the end of 2016, with only the wastewater treatment facility left standing as of February 2017.

[5] An initial proposal to have the site developed as a solar farm fell through when regulatory approval was not obtained,[5] but decommissioning was completed in 2019, with the property becoming available for sale.